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PL (Prelimbic area) functionally connects to BLA (basal amygdaloid nucleus)
All claims for this connection- Species
- Rat
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- With ChR2 driven by the CaMKIIα promoter in PL and fibers over PL terminals in BLA, 15 Hz illumination increased avoidance and reinstated it after extinction, while ArchT-mediated silencing of the same PL terminals in BLA impaired avoidance; the authors treat this as a necessary excitatory PL-to-BLA pathway.
- Source
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020
DOI 10.7554/elife.59281 · PubMed 33054975 · PMC7588229, Fig. 2A-H; Results, 'PL projections to the BLA'Licence: CC-BY-4.0
- Named in the paper
- “prelimbic (PL) PFC” and “basolateral amygdala (BLA)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-10
“Paper's ChR2 and ArchT terminal manipulations in BLA support a necessary excitatory PL→BLA pathway in rats, as located.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.