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AI (Agranular insular area) projects to CEA (Central amygdalar nucleus)

All claims for this connection
Species
Mouse
Result
present
Method
anterograde tracer
Sign
unknown
Strength
strong
Evidence
Cre-dependent synaptophysin-tdTomato expressed in FosTRAPed insular cortex neurons tagged during fear learning labelled presynaptic boutons predominantly in the central amygdala, showing that fear-memory-associated IC neurons send axons there.
Source

Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways

Nature Communications, 2022

DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 3e–i; Supplementary Fig. 4

Licence: CC-BY-4.0

Named in the paper
“IC (fear-memory ensembles)” and “CeA”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-09

“Anterograde bouton labeling from fear-tagged IC neurons showed extensive CeA innervation.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.