Mouse
AI (Agranular insular area) projects to CEA (Central amygdalar nucleus)
5 claims from 4 sources: 5 found, 0 tested and absent, 0 ambiguous. Evidence: anterograde tracer, retrograde tracer. Strongest reported: strong.
The claims behind it
Retrograde tracer injected into the central amygdala labelled insular cortex neurons, mainly in layer 5 with an additional population in layer 2/3; these cells were largely separate from accumbens-projecting IC cells.
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 5a–e; Results (Nonoverlapping IC-CeA and IC-NAc projectors)Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Cre-dependent synaptophysin-tdTomato expressed in FosTRAPed insular cortex neurons tagged during fear learning labelled presynaptic boutons predominantly in the central amygdala, showing that fear-memory-associated IC neurons send axons there.
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 3e–i; Supplementary Fig. 4Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Retrograde colour-switching AAV from the CeA labelled 22630 insular cortex neurons, 55% Oprm1-positive.
DOI 10.1038/s41386-025-02298-7 · PubMed 41419678 · PMC13125285, Fig. 5eMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
The central amygdala clearly received labelled insular projections.
DOI 10.1007/s12035-026-06153-8 · PubMed 42642694 · PMC13506595, Fig. 4b–d, gMade by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.
eYFP-positive axons arising from CaMKIIa-expressing anterior insular neurons were also detected in the central amygdala, although the mean fluorescence intensity of these terminals was significantly lower than that measured in the basolateral amygdala.
DOI 10.1007/s00213-023-06499-0 · PubMed 38010515 · PMC10884150, Fig. 3b, c; Results, aIC-AMY photoinhibition sectionMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.