clm-8ee5b6yvn6

Rat central amygdala corticotropin-releasing hormone-expressing neurons functionally connects to BST (Bed nuclei of the stria terminalis)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: In BNST slices from Crh-Cre rats with NpHR expressed in CeA CRF neurons, green-light inhibition of the CRF CeA-BNST terminals reduced action potential firing of BNST neurons (8 of 14 cells responded with reduced firing, 6 were non-responders; 6.5 s light: 0.37 to 0.22 Hz; 5 min light: 0.91 to 0.60 Hz). Pretreatment with the CRF1 receptor antagonist R121919 itself lowered BNST firing and occluded the light effect, indicating the terminal influence on BNST firing is driven by CRF acting on CRF1 receptors.
Measurements: connection probability: 0.571, n = 14
Source: Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
Nature Communications, 2019
DOI 10.1038/s41467-019-09183-0 · PubMed 30886240 · PMC6423296, Fig. 5f–i; Supplementary Figure 8; Supplementary Figure 4C,D
Licence: CC-BY-4.0
Named in the paper: “CRF CeA-BNST terminals” and “BNST”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Slice recordings with terminal photoinhibition show reduced BNST firing in 8 of 14 cells (0.571), occluded by R121919, matching the cited figures.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.