Rat

Rat central amygdala corticotropin-releasing hormone-expressing neurons functionally connects to BST (Bed nuclei of the stria terminalis)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-8ee5b6yvn6presentoptogenetic circuit mappingproposed

In BNST slices from Crh-Cre rats with NpHR expressed in CeA CRF neurons, green-light inhibition of the CRF CeA-BNST terminals reduced action potential firing of BNST neurons (8 of 14 cells responded with reduced firing, 6 were non-responders; 6.5 s light: 0.37 to 0.22 Hz; 5 min light: 0.91 to 0.60 Hz). Pretreatment with the CRF1 receptor antagonist R121919 itself lowered BNST firing and occluded the light effect, indicating the terminal influence on BNST firing is driven by CRF acting on CRF1 receptors.

DOI 10.1038/s41467-019-09183-0 · PubMed 30886240 · PMC6423296, Fig. 5f–i; Supplementary Figure 8; Supplementary Figure 4C,D

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.