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AI (Agranular insular area) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Optogenetic stimulation of insular axon terminals in the nucleus accumbens produced excitatory postsynaptic currents in accumbens neurons, which were suppressed by tetanus toxin expression in the presynaptic IC neurons.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 5b
Licence: CC-BY-4.0
Named in the paper: “IC-NAc projectors” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“ChR2-evoked oEPSCs in NAc neurons were reduced by TetTox in IC-NAc projectors.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.