Mouse

AI (Agranular insular area) functionally connects to ACB (Nucleus accumbens)

2 claims from 1 source: 2 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-8xmmnkr7fkpresentoptogenetic circuit mappingproposed

Optogenetic stimulation of insular axon terminals in the nucleus accumbens produced excitatory postsynaptic currents in accumbens neurons, which were suppressed by tetanus toxin expression in the presynaptic IC neurons.

DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 5b

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-xr2pd327e2presentoptogenetic circuit mappingproposed

Insular neurons labelled by the intersectional strategy as receiving orbitofrontal input and projecting to the accumbens produced excitatory postsynaptic currents in accumbens neurons when their terminals were photostimulated.

DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 25

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.