clm-a59nmx9e4y
PL (Prelimbic area) functionally connects to ACB (Nucleus accumbens)
All claims for this connection- Species
- Rat
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- ChR2 was expressed in PL under a CaMKIIα promoter and an optic fiber was placed over PL axon terminals in ventral striatum; blue-light stimulation at 4 Hz and 15 Hz of these terminals reduced platform-mediated avoidance in a frequency-dependent way, indicating a functional PL axonal input to ventral striatum. Photosilencing the same terminals with ArchT had no detectable behavioral effect.
- Source
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020
DOI 10.7554/elife.59281 · PubMed 33054975 · PMC7588229, Fig. 1B-E; Results, 'PL projections to the VS'Licence: CC-BY-4.0
- Named in the paper
- “prelimbic (PL) PFC” and “ventral striatum (VS)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-10
“Photoactivation of PL terminals in VS reduced avoidance at both frequencies with no effect of ArchT silencing, matching Figure 1 and the text.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.