clm-acd9vd0ccs

PB (Parabrachial nucleus) functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: In acute slices, red-light activation of C1ChrimsonSA expressed in parabrachial axons evoked excitatory postsynaptic currents in whole-cell recorded CeA neurons (isolated with picrotoxin), and photoactivation of presynaptically targeted bPAC potentiated these currents with a concurrent drop in paired-pulse ratio, indicating a functional monosynaptic excitatory PB-to-CeA input with presynaptically regulated release.
Source: All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals
Cell Reports Methods, 2024
DOI 10.1016/j.crmeth.2024.100740 · PubMed 38521059 · PMC11045876, Figs. 4A–4D, 5A–5B
Licence: CC-BY-NC-ND-4.0
Named in the paper: “PB” and “CeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optically evoked EPSCs in CeA neurons from PB-expressed C1ChrimsonSA with PPR changes support an excitatory functional PB→CeA connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.