clm-afqf06fh2e

Isocortex projects to CA1 (Field CA1)

Species: Mouse
Result: ambiguous
Method: retrograde tracer
Sign: unknown
Evidence: Retrograde AAV2rg-Cre injected into CA1 produced distinct HA-positive neurons in the prefrontal cortex. The authors say these may be direct hippocampal projections, but they may also reflect virus that leaked into cortex during the injection.
Source: Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus
Brain, Behavior, & Immunity - Health, 2025
DOI 10.1016/j.bbih.2024.100908 · PubMed 39720627 · PMC11667635, Fig. 7B; Results, prefrontal cortex projection neurons section
Licence: CC-BY-NC-ND-4.0
Named in the paper: “prefrontal cortex” and “CA1 of the hippocampus”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Fig. 7B shows HA-positive prefrontal neurons after CA1 retrograde injection, and the authors leave open whether they are direct projections or labelled by cortical leakage, so 'ambiguous' fits.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.