Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus

Isocortex MBA:315 projects to CA1 (Field CA1) MBA:382 · Mouse

Retrograde AAV2rg-Cre injected into CA1 produced distinct HA-positive neurons in the prefrontal cortex. The authors say these may be direct hippocampal projections, but they may also reflect virus that leaked into cortex during the injection.

Fig. 7B; Results, prefrontal cortex projection neurons section

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DG (Dentate gyrus) MBA:726 projects to CA1 (Field CA1) MBA:382 · Mouse

Four weeks after retrograde AAV2rg-Cre injection into CA1, HA-positive cells appeared in hippocampal subregions including the dentate gyrus. The authors describe these as regions that project to CA1.

Fig. 4C

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to CA1 (Field CA1) MBA:382 · Mouse

After bilateral injection of retrograde AAV2rg-Cre into CA1 of RiboTag mice, HA-labelled neurons were seen in the basolateral amygdala, indicating that BLA neurons project directly to the hippocampus. These labelled cells did not overlap with PV staining.

Fig. 4D–E

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