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PL (Prelimbic area) projects to PAG (Periaqueductal gray)

All claims for this connection
Species
Mouse
Result
present
Method
retrograde tracer
Sign
unknown
Evidence
Retrograde AAV2/R carrying mCherry injected into the lateral/ventrolateral PAG labelled CaMKIIα-positive PrL neurons, almost all of them in layer 5 and distinct from the BLA-projecting population.
Measurements
  • fraction of labelled neurons: 0.93, n = 20
  • fraction of labelled neurons: 0.036, n = 20
Source

Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain

Journal of Clinical Investigation, 2023

DOI 10.1172/jci166356 · PubMed 36917193 · PMC10145931, Fig. 1A–C; Supplemental Fig. 1A–G

Licence: CC-BY-4.0

Named in the paper
“PrL” and “l/vlPAG”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-09

“Retrograde AAV from l/vlPAG labelled CaMKIIα PrL neurons with ~93% in layer 5 and 3.6% in layer 2/3, n=20 slices, as stated.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.