clm-bxt2e7b7sg

BLA (Basolateral amygdalar nucleus) functionally connects to PL (Prelimbic area)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Silencing NpHR-expressing BLA axons within the prelimbic cortex with amber light increased the calcium transient rate of CaMKII-positive prefrontal neurons imaged by miniscope, both in the home cage and during social testing, showing that BLA input exerts a net suppressive influence on prefrontal excitatory neurons.
Source: Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations
Communications Biology, 2026
DOI 10.1038/s42003-026-10089-z · PubMed 42026195 · PMC13316100, Fig. 4d, f; Supplementary Fig. 4b
Licence: CC-BY-NC-ND-4.0
Named in the paper: “BLA” and “mPFC (PL) pyramidal neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“NpHR silencing of BLA axons in PL increased mPFC pyramidal transient rates, supporting net suppressive influence.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.