Mouse
BLA (Basolateral amygdalar nucleus) functionally connects to PL (Prelimbic area)
3 claims from 3 sources: 3 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping. Strongest reported: weak.
The claims behind it
Optogenetic activation of ChR2-expressing BLA axons in PL evoked only weak responses in ChCs relative to neighbouring pyramidal cells (charge ratio about 0.35).
DOI 10.1038/nn.4624 · PubMed 28825718 · PMC5614838, Fig. 4h-iMade by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.
Rhythmic optogenetic driving of BLA parvalbumin interneurons at 4 Hz or 8 Hz shifted not only the BLA local field potential spectrum but also the mPFC spectrum toward the stimulation frequency, and changed the BLA–mPFC cross-power spectrum, indicating that activity imposed in the BLA propagates to and is amplified in mPFC (in a memory-state dependent way for the cross-power measure).
DOI 10.1038/s41467-020-18199-w · PubMed 32868768 · PMC7459312, Results, 'Effects of BLA stimulation on BLA-mPFC oscillatory activity'; Supplementary Fig. 4d,f; Fig. 5d–iMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
After expressing ChR2 in BLA neurons, blue-light pulses delivered through a probe in the mPFC evoked local field responses at a short latency (~5 ms after each pulse), appearing about 12 days post-injection; a second, longer-latency (~32 ms) component appeared later and was attributed by the authors to polysynaptic network activity within the mPFC.
DOI 10.1038/nn.4510 · PubMed 28218915 · PMC5374019, Fig. 3j; Results, projection mapping sectionMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The paper records from and names only the mPFC, never the prelimbic area specifically, so the object region is narrower than the paper's own region.”