clm-cgb3fpkrrz

BLA (Basolateral amygdalar nucleus) functionally connects to CP (Caudoputamen)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Light activation of ChR2-expressing BLA axons evoked excitatory postsynaptic currents in D1-expressing medium spiny neurons of the dorsomedial striatum, which were larger than those in D2 neurons across stimulation intensities; the AMPA/NMDA ratio of these BLA-evoked currents in D1 neurons increased after chronic circuit activation (9 cells from 3 control mice vs 5 cells from 4 CNO-treated mice).
Source: Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice
Nature Communications, 2024
DOI 10.1038/s41467-023-44322-8 · PubMed 38191518 · PMC10774417, Fig. 2j,k; Fig. 6a-c
Licence: CC-BY-4.0
Named in the paper: “BLA” and “D1-MSNs (tdTomato+) in the DMS”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetically evoked EPSCs in D1-MSNs and the increased AMPA/NMDA ratio after chronic activation match the paper's Fig. 2k and 6c numbers.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.