clm-cn4k63m6v1

HPF (Hippocampal formation) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light stimulation of ChR2-expressing ventral hippocampal afferents elicited glutamatergic AMPA/NMDA EPSCs and EPSPs in accumbens medium spiny neurons (n = 15 cells tested for plasticity), supporting both spike-timing dependent LTP and LTD; these synapses had a highly variable AMPA/NMDA ratio (mean 5.7) and weaker magnesium block of NMDA currents than cortical or amygdala inputs.
Source: The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens
Frontiers in Synaptic Neuroscience, 2015
DOI 10.3389/fnsyn.2015.00012 · PubMed 26257641 · PMC4507144, Figs. 2H–K, 3, 4, 5, 6, 8C–D
Named in the paper: “ventral (ventrolateral) hippocampus” and “nucleus accumbens (NAc) MSNs”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Hippocampal inputs gave tLTD and tLTP in 15 cells, a variable AMPA/NMDA ratio averaging 5.7 and weaker Mg2+ block, all reported in the results.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.