Mouse

HPF (Hippocampal formation) functionally connects to ACB (Nucleus accumbens)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-cn4k63m6v1presentoptogenetic circuit mappingproposed

Blue-light stimulation of ChR2-expressing ventral hippocampal afferents elicited glutamatergic AMPA/NMDA EPSCs and EPSPs in accumbens medium spiny neurons (n = 15 cells tested for plasticity), supporting both spike-timing dependent LTP and LTD; these synapses had a highly variable AMPA/NMDA ratio (mean 5.7) and weaker magnesium block of NMDA currents than cortical or amygdala inputs.

DOI 10.3389/fnsyn.2015.00012 · PubMed 26257641 · PMC4507144, Figs. 2H–K, 3, 4, 5, 6, 8C–D

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