clm-d7x27mcms4
BLA glutamatergic principal neurons functionally connects to ACA (Anterior cingulate area)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Blue-light stimulation of ChR2-expressing BLA glutamatergic terminals evoked postsynaptic currents in layer II/III ACC pyramidal neurons that were abolished by the AMPA-receptor blocker CNQX; the responses were eliminated by TTX and restored by TTX plus 4-AP, indicating a direct monosynaptic excitatory input. In the pain/anxiety model these light-evoked currents were larger and the paired-pulse ratio was lower than in controls.
- Source
Theranostics, 2025
DOI 10.7150/thno.111130 · PubMed 40225572 · PMC11984391, Fig. 6G-L; Fig. 8B-E- Named in the paper
- “BLAGlu neurons” and “ACC pyramidal neurons (layers II/III)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-10
“The light-evoked EPSCs in ACC layer II/III neurons were blocked by CNQX and by TTX, then rescued by 4-AP, showing a monosynaptic excitatory input; in the model they were larger and had a lower PPR (Fig. 8B-E).”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.