BLA glutamatergic principal neurons functionally connects to ACA (Anterior cingulate area)

Blue-light stimulation of ChR2-expressing BLA glutamatergic terminals evoked postsynaptic currents in layer II/III ACC pyramidal neurons that were abolished by the AMPA-receptor blocker CNQX; the responses were eliminated by TTX and restored by TTX plus 4-AP, indicating a direct monosynaptic excitatory input. In the pain/anxiety model these light-evoked currents were larger and the paired-pulse ratio was lower than in controls.

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