clm-da9418gd3g
AI (Agranular insular area) functionally connects to CEAm (Central amygdalar nucleus, medial part)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Optogenetic activation of insular axons evoked EPSCs in CeM neurons that persisted under TTX+4AP and were blocked by AP5+NBQX, showing direct glutamatergic input. IPSCs disappeared under TTX+4AP, so they were polysynaptic.
- Source
Linking emotional valence and anxiety in a mouse insula-amygdala circuit
Nature Communications, 2023
DOI 10.1038/s41467-023-40517-1 · PubMed 37604802 · PMC10442438, Fig. 4a-gLicence: CC-BY-4.0
- Named in the paper
- “IC” and “CeM”
- Made by
- an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-09
“CeM oEPSCs partly survived TTX+4AP and were abolished by glutamate antagonists, while oIPSCs were abolished by network blockade.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.