clm-e4a03mhs2x
ENT (Entorhinal area) functionally connects to BLA glutamatergic principal neurons
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Optogenetic activation of ChrimsonR-expressing entorhinal CCK neurons in CCK-Cre mice rapidly increased GCaMP6s calcium signals in CaMKII-positive BLA neurons, and the same stimulation elevated a BLA CCK sensor signal; the calcium response was strongly reduced after the mGluR5 agonist DHPG.
- Source
mGluR5 in EC CCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, 2026
DOI 10.1002/advs.202523115 · PubMed 42102389 · PMC13335908, Fig. 1E–I; Fig. 5E–J, M–OLicence: CC-BY-4.0
- Named in the paper
- “ECCCK neurons” and “BLAGlu neurons”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-08
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-08
“Photometry during ChrimsonR activation of EC CCK neurons showed increased BLA CaMKII calcium and CCK sensor signals, reduced by DHPG.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.