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BLAa (Basolateral amygdalar nucleus, anterior part) functionally connects to PL (Prelimbic area)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Light activation of ChR2-expressing rBLA axons in slices evoked monosynaptic glutamatergic currents (isolated with TTX, 4-AP and raised Ca2+) that were far larger in PL layer 2 cortico-amygdalar neurons than in any other recorded projection neuron, and sCRACM showed the input lands on basal and perisomatic dendrites. In current clamp these inputs reliably drove action potentials (firing probability 0.88 ± 0.05, 8 pairs). Responses were also larger at PL L2 CA cells than neighbouring L2 cortico-cortical cells.
Source: Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex
eLife, 2022
DOI 10.7554/elife.82688 · PubMed 36476757 · PMC9803354, Fig. 2C, 2F; Fig. 3A,B,E; Fig. 2—figure supplement 1A–C
Licence: CC-BY-4.0
Named in the paper: “rBLA” and “PL L2 cortico-amygdalar (CA) neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“rBLA evoked the largest monosynaptic perisomatic EPSCs and reliable firing in PL L2 CA neurons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.