clm-f7p58tfeac

SSp-ll (Primary somatosensory area, lower limb) projects to BLA (Basolateral amygdalar nucleus)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: A retrograde AAV (AAV2/Retro-hSyn-EGFP) injected into the BLA labelled cell bodies in S1, concentrated in the hind limb region and mainly in layer 5. RNAscope showed that roughly 90% of these retrogradely labelled cells contained Slc17a7 mRNA, indicating glutamatergic projection neurons.
Measurements: fraction of labelled neurons: 0.9
Source: The primary somatosensory sensory cortex-basolateral amygdala pathway contributes to comorbid depression in spared nerve injury-induced neuropathic pain
Scientific Reports, 2025
DOI 10.1038/s41598-025-97164-3 · PubMed 40258918 · PMC12012082, Fig. 3A1-A4, 3B; Results section on circuit architecture
Licence: CC-BY-NC-ND-4.0
Named in the paper: “S1HL (hind limb region of the primary somatosensory cortex)” and “BLA (basolateral amygdala)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Retro-AAV from BLA labelled layer-5 S1HL somas with ~90% Slc17a7 colocalization, as described for Fig. 3A-B.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.