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BLA parvalbumin-expressing interneurons functionally connects to LA glutamatergic principal neurons

All claims for this connection
Species
Mouse
Result
present
Method
optogenetic circuit mapping
Sign
inhibitory
Evidence
After Cre-dependent ChR2 expression in parvalbumin interneurons of the basolateral amygdala, blue-light pulses evoked inhibitory postsynaptic currents in lateral amygdala principal neurons recorded with glutamate receptor blockers present; paired-pulse ratios differed between genotypes, indicating a lower GABA release probability when Mecp2 was deleted from the PV cells.
Source

Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity

Molecular Autism, 2026

DOI 10.1186/s13229-025-00699-5 · PubMed 41491494 · PMC12829049, Fig. 1b; Results, section on PV output

Licence: CC-BY-4.0

Named in the paper
“PV interneurons (ChR2-expressing parvalbumin interneurons of the BLA)” and “principal neurons (PNs) in the lateral amygdala”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5-5) agrees, 2026-10-09

“The paper shows that light-evoked GABA release from ChR2-expressing PV cells produces IPSCs in LA principal neurons under AMPA/NMDA block, with PPR differing by genotype (Fig. 1b).”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.