clm-fs7wm83gvm
VTA (Ventral tegmental area) functionally connects to CEA (Central amygdalar nucleus)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Blue-light stimulation of ChR2-expressing VTA glutamatergic axon terminals in the CeA raised c-Fos expression in CeA neurons relative to unstimulated controls, and the same terminal stimulation drove rapid, frequency-dependent NREM-to-wake transitions and sustained wakefulness, indicating a functional driving input from VTA glutamatergic neurons to the CeA.
- Source
Control of Behavioral Arousal and Defense by a Glutamatergic Midbrain-Amygdala Pathway in Mice
Frontiers in Neuroscience, 2022
DOI 10.3389/fnins.2022.850193 · PubMed 35527820 · PMC9070111, Fig. 4C,D; Fig. 5B-FLicence: CC-BY-4.0
- Named in the paper
- “VTA” and “CeA”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-10
“Terminal photostimulation in CeA increased CeA c-Fos and drove wakefulness, supporting an excitatory functional VTA→CeA input in mice.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.