clm-ggyd11p05m
VM (Ventral medial nucleus of the thalamus) functionally connects to PL (Prelimbic area)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- modulatory
- Evidence
- ChR2 was expressed in VM GRP neurons and light was delivered through a fibre placed over the mPFC; stimulation of these VM axon terminals in the mPFC produced significantly more scratching than in mCherry controls, indicating a functional GRPergic VM-to-mPFC pathway.
- Source
A prefrontal peptidergic circuit for psychogenic itch
Science Advances, 2026
DOI 10.1126/sciadv.aed8901 · PubMed 42585325 · PMC13464479, Fig. 3F- Named in the paper
- “GRP neurons in VM (VM→mPFC terminals)” and “mPFC”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Fig. 3F shows opto activation of VM GRP terminals in mPFC increased scratching, supporting a functional VM→mPFC peptidergic link.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.