clm-h07cdnz93f

MPO (Medial preoptic area) projects to PAG (Periaqueductal gray)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: Injection of a retrogradely infecting AAV driving Cre into the caudolateral PAG, combined with a Cre-dependent reporter/ChR2 in the preoptic area, labelled POA cell bodies, demonstrating a preoptic projection to the PAG. All 319 labelled POA-to-PAG cells expressed VGAT and 278 of 319 co-expressed Esr1.
Source: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization
eLife, 2020
DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 2A, 2C; Fig. 4—figure supplement 2
Licence: CC-BY-4.0
Named in the paper: “POA” and “caudolateral PAG”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Retro-Cre labelled POAPAG cells, with 319/319 VGAT-positive and 278/319 Esr1-positive.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.