Mouse

MPO (Medial preoptic area) projects to PAG (Periaqueductal gray)

3 claims from 2 sources: 3 found, 0 tested and absent, 0 ambiguous. Evidence: anterograde tracer, retrograde tracer. Strongest reported: strong.

The claims behind it

clm-7df6tqm96dpresentanterograde tracerproposed

GFP-labeled POA neurons that project to AmgC/M also had axon terminals in the caudolateral PAG where PAG-USV neurons reside, indicating collateral projections.

DOI 10.7554/elife.85547 · PubMed 37314164 · PMC10353859, Fig. 6C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

clm-h07cdnz93fpresentretrograde tracerproposed

Injection of a retrogradely infecting AAV driving Cre into the caudolateral PAG, combined with a Cre-dependent reporter/ChR2 in the preoptic area, labelled POA cell bodies, demonstrating a preoptic projection to the PAG. All 319 labelled POA-to-PAG cells expressed VGAT and 278 of 319 co-expressed Esr1.

DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 2A, 2C; Fig. 4—figure supplement 2

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

clm-hezk4jkaz4presentanterograde tracerstrength: strongproposed

GFP labelling of PAG-projecting preoptic neurons revealed dense terminal fields in the caudolateral PAG that overlapped with those of AmgC/M-PAG neurons.

DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 2—figure supplement 3 (bottom right)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.