clm-h9ta46xgwr

VTA (Ventral tegmental area) functionally connects to BLA (Basolateral amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: unknown
Evidence: In slices from wildtype mice, light stimulation of ChR2-expressing VTA terminals raised the frequency of spontaneous EPSPs in BLA neurons. It did not change sEPSP amplitude or sIPSP frequency or amplitude. In Grp-/- mice, baseline sEPSP frequency was already high and light did not change it further.
Source: Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction
Molecular Psychiatry, 2024
DOI 10.1038/s41380-024-02843-8 · PubMed 39580604 · PMC12092189, Fig. 5C-J
Licence: CC-BY-4.0
Named in the paper: “VTA” and “BLA neurons”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“In wildtype slices, light activation of VTA terminals raised BLA sEPSP frequency with no other changes, and the Grp-/- result also matches (Fig. 5C-J).”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.