clm-hp614cpxy4

LC (Locus ceruleus) functionally connects to BLA (Basolateral amygdalar nucleus)

All claims for this connection

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Light activation of ChR2-expressing LC terminals in BLA slices evoked catecholamine transients with voltammetric signatures of norepinephrine (clearance t1/2 about 2 s) that fell to roughly a third of baseline after reserpine. In vivo, the same terminal stimulation raised firing in a fifth of recorded BLA units and suppressed firing in a smaller fraction, with long response latencies indicating a neuromodulatory rather than fast monosynaptic action, and increased BLA cFos relative to opsin-negative and contralateral controls; intra-BLA beta-adrenergic blockade abolished the behavioural consequence.
Measurements: connection probability: 0.214, n = 42
connection probability: 0.095, n = 42
conduction delay: 129.3 ms (SD 108.9), n = 9
conduction delay: 172.6 ms (SD 77.01), n = 4
Source: Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior
eLife, 2017
DOI 10.7554/elife.18247 · PubMed 28708061 · PMC5550275, Fig. 2C–F; Fig. 3C–K; Fig. 4B
Licence: CC-BY-4.0
Named in the paper: “LC” and “BLA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“Voltammetry, single-unit proportions (21.4%/9.5% of 42 units), latencies and cFos/propranolol data match the paper.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.