Mouse

LC (Locus ceruleus) functionally connects to BLA (Basolateral amygdalar nucleus)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-hp614cpxy4presentoptogenetic circuit mappingproposed

Light activation of ChR2-expressing LC terminals in BLA slices evoked catecholamine transients with voltammetric signatures of norepinephrine (clearance t1/2 about 2 s) that fell to roughly a third of baseline after reserpine. In vivo, the same terminal stimulation raised firing in a fifth of recorded BLA units and suppressed firing in a smaller fraction, with long response latencies indicating a neuromodulatory rather than fast monosynaptic action, and increased BLA cFos relative to opsin-negative and contralateral controls; intra-BLA beta-adrenergic blockade abolished the behavioural consequence.

DOI 10.7554/elife.18247 · PubMed 28708061 · PMC5550275, Fig. 2C–F; Fig. 3C–K; Fig. 4B

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