clm-hz865z4bdh

MPO (Medial preoptic area) functionally connects to PAG (Periaqueductal gray)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Optogenetic activation of ChR2-expressing preoptic axons within the PAG evoked IPSCs in 26 of 36 fluorescently identified VGAT+ PAG neurons (mean ~329 pA at 0 mV); the currents persisted in TTX/4AP and were blocked by gabazine, indicating direct GABAergic synapses.
Measurements: connection probability: 0.722, n = 36
Source: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization
eLife, 2020
DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 6A–D
Licence: CC-BY-4.0
Named in the paper: “POAPAG axons” and “VGAT+ PAG neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“26 of 36 VGAT+ cells showed TTX-resistant, gabazine-sensitive IPSCs, which matches 0.722.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.