Mouse

MPO (Medial preoptic area) functionally connects to PAG (Periaqueductal gray)

2 claims from 1 source: 1 found, 0 tested and absent, 1 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-hz865z4bdhpresentoptogenetic circuit mappingproposed

Optogenetic activation of ChR2-expressing preoptic axons within the PAG evoked IPSCs in 26 of 36 fluorescently identified VGAT+ PAG neurons (mean ~329 pA at 0 mV); the currents persisted in TTX/4AP and were blocked by gabazine, indicating direct GABAergic synapses.

DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 6A–D

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

clm-k27nvksvcxambiguousoptogenetic circuit mappingproposed

When preoptic axons in the PAG were optogenetically stimulated, IPSCs were detected in only 1 of 23 recorded PAG-USV neurons, even though IPSCs could be evoked in neighbouring unlabelled cells, suggesting few or weak direct preoptic synapses onto PAG-USV neurons.

DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 6—figure supplement 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.