clm-jh48a2me4y

MEA GABAergic neurons functionally connects to ARH (Arcuate hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: unknown
Evidence: Optogenetic activation of the whole MePD GABA population in VGAT-Cre mice expressing ChR2 lengthened the LH inter-pulse interval (about 18.5 min before versus 49.5 min during stimulation, n = 5), whereas no-stimulation and control-virus groups showed no change, indicating that MePD GABA neuron activity suppresses the arcuate GnRH pulse generator that drives LH pulses.
Source: The role of amygdala GABA neurons in controlling stress and reproduction in female mice
Nature Communications, 2026
DOI 10.1038/s41467-026-70364-9 · PubMed 41807404 · PMC13319269, Fig. 6A–D
Licence: CC-BY-4.0
Named in the paper: “MePD GABA neurons (VGAT-Cre, ChR2)” and “hypothalamic GnRH pulse generator (arcuate KNDy network)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“VGAT-Cre ChR2 stimulation lengthened LH IPI from 18.5 to 49.5 min with n=5 and null controls, as claimed.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.