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Mouse

MEA GABAergic neurons functionally connects to ARH (Arcuate hypothalamic nucleus)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-jh48a2me4ypresentoptogenetic circuit mappingproposed

Optogenetic activation of the whole MePD GABA population in VGAT-Cre mice expressing ChR2 lengthened the LH inter-pulse interval (about 18.5 min before versus 49.5 min during stimulation, n = 5), whereas no-stimulation and control-virus groups showed no change, indicating that MePD GABA neuron activity suppresses the arcuate GnRH pulse generator that drives LH pulses.

DOI 10.1038/s41467-026-70364-9 · PubMed 41807404 · PMC13319269, Fig. 6A–D

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