clm-jyzp993z6h

AI (Agranular insular area) functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light activation of ChR2-expressing insular axon terminals in the central amygdala evoked excitatory postsynaptic currents in recorded CeA neurons; these currents were strongly reduced when tetanus toxin light chain was expressed in the same IC neurons.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 5b
Licence: CC-BY-4.0
Named in the paper: “IC-CeA projectors” and “CeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetic stimulation of IC terminals evoked oEPSCs in CeA, reduced by TetTox.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.