Mouse

AI (Agranular insular area) functionally connects to CEA (Central amygdalar nucleus)

2 claims from 1 source: 1 found, 1 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-jyzp993z6hpresentoptogenetic circuit mappingproposed

Blue-light activation of ChR2-expressing insular axon terminals in the central amygdala evoked excitatory postsynaptic currents in recorded CeA neurons; these currents were strongly reduced when tetanus toxin light chain was expressed in the same IC neurons.

DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 5b

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-pabsmpmc90absentoptogenetic circuit mappingproposed

Photostimulating the terminals of the same intersectionally labelled insular neurons failed to evoke excitatory currents in central amygdala neurons, confirming the pathway's selectivity for the accumbens.

DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 25

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.