clm-k27nvksvcx

MPO (Medial preoptic area) functionally connects to PAG (Periaqueductal gray)

Species: Mouse
Result: ambiguous
Method: optogenetic circuit mapping
Sign: unknown
Evidence: When preoptic axons in the PAG were optogenetically stimulated, IPSCs were detected in only 1 of 23 recorded PAG-USV neurons, even though IPSCs could be evoked in neighbouring unlabelled cells, suggesting few or weak direct preoptic synapses onto PAG-USV neurons.
Measurements: connection probability: 0.043, n = 23
Source: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization
eLife, 2020
DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 6—figure supplement 1
Licence: CC-BY-4.0
Named in the paper: “POAPAG axons” and “PAG-USV neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Only 1 of 23 PAG-USV cells responded, about 0.043, which is a sparse and inconclusive connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.