clm-kg3x229q7z

MEA (Medial amygdalar nucleus) functionally connects to PVH (Paraventricular hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: unknown
Evidence: Blue-light stimulation (20 Hz, 15 mW) of ChR2-expressing MePD Ucn3 axon terminals within the PVN raised circulating corticosterone relative to control virus animals, indicating that the MePD Ucn3 input drives PVN-dependent HPA axis output; no such change occurred in AAV-YFP controls.
Source: Posterodorsal Medial Amygdala Urocortin-3, GABA, and Glutamate Mediate Suppression of LH Pulsatility in Female Mice
Endocrinology, 2022
DOI 10.1210/endocr/bqac196 · PubMed 36445688 · PMC9761574, Fig. 2; Results, 'Effect of MePD Urocortin-3 Terminal Stimulation in the PVN on Dynamic CORT Secretion'
Licence: CC-BY-NC-ND-4.0
Named in the paper: “MePD Ucn3 neurons” and “hypothalamic paraventricular nucleus (PVN)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Terminal optogenetic stimulation in PVN raised CORT vs controls, supporting a functional MePD Ucn3 to PVN connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.