clm-kj41qyrdw7

CEA (central amygdaloid nucleus) projects to PB (Parabrachial nucleus)

Species: Rat
Result: present
Method: anterograde tracer
Sign: inhibitory
Evidence: Cre-dependent synaptophysin-mRuby expressed in GAD1-positive central amygdala neurons of Gad1-iCre rats produced red synaptophysin puncta in the lateral parabrachial nucleus, where they colocalized with CaMKIIa-EGFP-labelled excitable neurons across serial optical z-sections; puncta per CaMKIIa cell and the number of CaMKIIa cells bearing puncta were reduced by Nrxn3 knockdown in the central amygdala and puncta number was increased by whisker-pad VZV injection.
Source: Neurexin 3 Regulates Synaptic Connections Between Central Amygdala Neurons and Excitable Cells of the Lateral Parabrachial Nucleus in Rats with Varicella Zoster Induced Orofacial Pain
Journal of Pain Research, 2024
DOI 10.2147/jpr.s441706 · PubMed 38974829 · PMC11227312, Figs. 4C–N, 5A–R
Licence: CC-BY-NC-3.0
Named in the paper: “central amygdala” and “lateral parabrachial nucleus”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“Cre-dependent synaptophysin labeling in Gad1-iCre rat central amygdala yielded puncta on CaMKIIa-EGFP cells in lateral parabrachial nucleus, with the described shRNA and VZV effects, and the GABAergic source supports an inhibitory sign.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.