clm-kq0vfxre6s

PB (Parabrachial nucleus) functionally connects to CEAl PKC-delta-expressing neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light stimulation of ChR2-expressing PBN terminals in CeA slices from Prkcd-cre::Ai9 mice evoked optically evoked EPSCs in most recorded PKCδ+ neurons in the laterocapsular CeA, regardless of whether the cells were late-firing or regular-spiking.
Measurements: connection probability: 0.8, n = 10
Source: The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice
Neuropsychopharmacology, 2023
DOI 10.1038/s41386-023-01673-6 · PubMed 37542159 · PMC10789863, Fig. 1C–F; Results, section 1
Licence: CC-BY-4.0
Named in the paper: “parabrachial nucleus (PBN)” and “CeA-PKCδ+ neurons”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“The paper reports oEPSCs in 80% of 10 recorded CeA-PKCδ+ cells, regardless of whether they were late-firing or regular-spiking.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.