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AI (Agranular insular area) functionally connects to BLA (Basolateral amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Brief blue-light stimulation of ChR2-expressing insular cortex glutamatergic terminals in slices evoked postsynaptic currents in BLA neurons, and these currents were abolished by the AMPA-receptor antagonist DNQX, indicating a glutamatergic excitatory connection.
Source: Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain
Journal of Biological Chemistry, 2022
DOI 10.1016/j.jbc.2022.102207 · PubMed 35772494 · PMC9304789, Fig. 5, C and D
Licence: CC-BY-4.0
Named in the paper: “ICGlu” and “BLA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Fig. 5C, D show DNQX-blockable light-evoked currents in BLA neurons from IC glutamatergic terminals.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.