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clm-nm56a1agpn

PL (Prelimbic area) synapses onto PVH (Paraventricular hypothalamic nucleus)

All claims for this connection
Species
Mouse
Result
present
Method
transsynaptic tracer
Sign
unknown
Evidence
Anterograde transsynaptic labelling with AAV1-hSyn-Cre in the PrL of Ai14 reporter mice (with AAV5-hSyn-DIO-EGFP in the PVN) produced labelled PVN neurons that co-expressed the GABAergic marker GAD67, indicating that prelimbic axons contact PVN inhibitory neurons.
Source

Conditional deletion of Cc2d1a increases irritability-like behavior by decreasing oxytocin expression via the prelimbic-hypothalamic pathway

Journal of Biomedical Science, 2026

DOI 10.1186/s12929-026-01263-w · PubMed 42231358 · PMC13227712, Fig. 6C–F

Licence: CC-BY-4.0

Named in the paper
“PrL” and “GABAergic (GAD67+) neurons in the PVN”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-09

“Transsynaptically labeled PVN neurons colocalized with GAD67, indicating PrL contacts PVN GABAergic cells, though the GAD67 panel used only the PrL AAV1-Cre injection.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.