clm-p5y5gm5kb8

PVT (Paraventricular nucleus of the thalamus) functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Chrimson was expressed in pPVT CaMKIIα+ neurons and GCaMP6s in CeA GABAergic neurons of VGAT-Cre mice; red-light stimulation of pPVT terminals within the CeA increased the calcium signal of CeA GABAergic neurons, with a larger area under the curve than in mCherry controls, indicating a predominantly excitatory functional connection.
Source: The pPVTglu- CeAGABA circuit is involved in regulating hyperalgesia in the chronic NTG mouse model in males
The Journal of Headache and Pain, 2026
DOI 10.1186/s10194-026-02285-3 · PubMed 41652327 · PMC12977853, Fig. 6A-E
Licence: CC-BY-NC-ND-4.0
Named in the paper: “pPVT” and “CeA GABAergic neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetic terminal activation plus photometry showed excitatory drive of CeA GABAergic neurons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.