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ORB (Orbital area) synapses onto AI (Agranular insular area)

Species: Mouse
Result: present
Method: transsynaptic tracer
Sign: unknown
Evidence: Rabies tracing from amygdala-projecting insular neurons also labelled orbitofrontal cortex input cells, but fewer than for accumbens-projecting insular neurons.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 7b, c
Licence: CC-BY-4.0
Named in the paper: “OFC” and “IC-CeA projectors”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“OFC inputs to IC-CeA projectors were labeled but significantly fewer than to IC-NAc projectors.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.