Mouse
ORB (Orbital area) synapses onto AI (Agranular insular area)
3 claims from 1 source: 3 found, 0 tested and absent, 0 ambiguous. Evidence: transsynaptic tracer.
The claims behind it
Rabies-virus monosynaptic tracing from accumbens-projecting insular neurons labelled many presynaptic cells in the orbitofrontal cortex, significantly more than were labelled from amygdala-projecting insular neurons.
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 7a–cMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Rabies tracing from amygdala-projecting insular neurons also labelled orbitofrontal cortex input cells, but fewer than for accumbens-projecting insular neurons.
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 7b, cMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Anterograde transsynaptic AAV1 expressing Flp injected into the orbitofrontal cortex drove recombination in postsynaptic insular cortex neurons, which could then be targeted for further manipulation.
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 7f; Supplementary Fig. 24bMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.