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AI (Agranular insular area) functionally connects to BLN (basolateral amygdaloid nuclear complex)
All claims for this connection- Species
- Rat
- Result
- present
- Method
- electrical stimulation
- Sign
- inhibitory
- Evidence
- A conditioning electrical pulse in the lateral orbitofrontal cortex reduced the probability that mPFC stimulation evoked a spike in lateral/basolateral amygdala neurons, with significant suppression at lOFC-mPFC delays of 25-500 ms and no effect at 1000 ms. Nine of 11 neurons in Exp 1 and all 9 in Exp 2 were suppressed by the lOFC prepulse. Local iontophoresis of the GABA-A antagonist bicuculline abolished the suppression at both 25 and 100 ms delays, whereas the GABA-B antagonist saclofen reversed it only at the 100 ms delay, indicating the gating is mediated by intra-amygdala GABA receptors. Three of the 9 gated neurons in Exp 1 also received direct convergent input from the lOFC.
- Measurements
- connection probability: 0.818, n = 11
- connection probability: 1, n = 9
- Source
International Journal of Neuropsychopharmacology, 2017
DOI 10.1093/ijnp/pyx027 · PubMed 28444246 · PMC5492808, Results Exp 1 (Fig. 2B) and Exp 2 (Fig. 3B, Fig. 4)- Named in the paper
- “lateral orbitofrontal cortex (lOFC; LO/AIv)” and “LA/BLA”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Exp 1/2 show lOFC prepulse suppressing mPFC-evoked amygdala spiking (9/11 and 9/9 neurons) via intra-amygdala GABA receptors, matching the inhibitory sign and counts.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.