Rat

AI (Agranular insular area) functionally connects to BLN (basolateral amygdaloid nuclear complex)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: electrical stimulation.

The claims behind it

clm-q9kwygqwc8presentelectrical stimulationproposed

A conditioning electrical pulse in the lateral orbitofrontal cortex reduced the probability that mPFC stimulation evoked a spike in lateral/basolateral amygdala neurons, with significant suppression at lOFC-mPFC delays of 25-500 ms and no effect at 1000 ms. Nine of 11 neurons in Exp 1 and all 9 in Exp 2 were suppressed by the lOFC prepulse. Local iontophoresis of the GABA-A antagonist bicuculline abolished the suppression at both 25 and 100 ms delays, whereas the GABA-B antagonist saclofen reversed it only at the 100 ms delay, indicating the gating is mediated by intra-amygdala GABA receptors. Three of the 9 gated neurons in Exp 1 also received direct convergent input from the lOFC.

DOI 10.1093/ijnp/pyx027 · PubMed 28444246 · PMC5492808, Results Exp 1 (Fig. 2B) and Exp 2 (Fig. 3B, Fig. 4)

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