clm-qj2fwz0sgr
PVT (Paraventricular nucleus of the thalamus) functionally connects to ACB (Nucleus accumbens)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Light stimulation of ChR2-expressing PVT axons in accumbens slices evoked AMPAR/NMDAR excitatory currents in D2-eGFP medium spiny neurons; the AMPA/NMDA ratio of this input was elevated after morphine withdrawal and 1 Hz optical stimulation produced a lasting depression of the response (to about 31.5% of baseline, n = 16 neurons from 4 mice).
- Source
Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice
Journal of Clinical Investigation, 2023
DOI 10.1172/jci163266 · PubMed 37561576 · PMC10503809, Fig. 4A, B; Fig. 5A-CLicence: CC-BY-4.0
- Named in the paper
- “PVT” and “NAc D2 MSNs”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Optical PVT terminal stimulation evoked EPSCs in D2-eGFP MSNs with increased A/N and oLFS-induced depression to 31.5%±3.7% (n=16/4).”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.