Mouse

PVT (Paraventricular nucleus of the thalamus) functionally connects to ACB (Nucleus accumbens)

2 claims from 1 source: 2 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-qj2fwz0sgrpresentoptogenetic circuit mappingproposed

Light stimulation of ChR2-expressing PVT axons in accumbens slices evoked AMPAR/NMDAR excitatory currents in D2-eGFP medium spiny neurons; the AMPA/NMDA ratio of this input was elevated after morphine withdrawal and 1 Hz optical stimulation produced a lasting depression of the response (to about 31.5% of baseline, n = 16 neurons from 4 mice).

DOI 10.1172/jci163266 · PubMed 37561576 · PMC10503809, Fig. 4A, B; Fig. 5A-C

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clm-rd36w52fwqpresentoptogenetic circuit mappingproposed

Optically evoked excitatory postsynaptic currents from PVT terminals were also recorded in accumbens D1 medium spiny neurons; these responses were unchanged by 1 Hz optical low-frequency stimulation (about 104% of baseline, n = 9 neurons from 3 mice) and their AMPA/NMDA ratio was unaltered by morphine withdrawal.

DOI 10.1172/jci163266 · PubMed 37561576 · PMC10503809, Fig. 4B; Fig. 5C

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); not checked yet.